Volume 6,Issue 3
Application of Bioprinting Technology in the Construction of Vascularized Tissue-engineered Breasts
Reconstruction of the breast provides challenges to restore both form and function post-mastectomy. Traditional prostheses suffer from limitations such as periosteal contracture, tactile distortion, and the significant barrier of lacking a functional vascular supply in tissue-engineered breasts. 3D bioprinting represents a novel solution to the biomimetic construction of 3D breast models, and the hierarchical vascular network bioprinted into space can be precisely controlled through the ordered deposition of cells and biomaterials. The value of 3D bioprinting stems from its ability to transcend the physical constraints of nutrient infiltration and blood perfusion in vascularized tissue engineering and convert static scaffolds into living, metabolically-active tissue. The current trajectory of bioprinting research includes bionic design of multi-scale vascular topology, functional induction of endothelialized microchannels, and kinetic mechanisms of in vivo integration of printed tissue, all of which aspire to reduce the gap between mere morphological mimicry and reconstruction of physiological function.
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