ARTICLE
26 September 2025

How Should We Deal with the Failure of Antibiotics Draft I

Jiangxiong Wang*
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1 Beijing National Day School, Building 15, Ocean View Qinshanshan, No. 805, Shishao Zhongjie, Shijingshan District, Beijing 100043, China
© 2025 by the Author. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

The discovery and development of antibiotics have revolutionized modern medicine, saving millions of lives and reshaping global public health. However, antibiotic resistance has emerged as a formidable challenge, driven by clinical misuse, agricultural overuse, and environmental neglect. This review outlines the historical trajectory of antibiotics, from Fleming’s discovery of penicillin to the current AI-assisted discovery approaches. We classify commonly used antibiotics, summarize their mechanisms of action, and discuss the societal and medical significance of antibiotics. Moreover, we analyze the underlying causes of the growing antibiotic resistance crisis and propose targeted strategies—including regulation, education, and technological innovation—to safeguard the efficacy of antibiotics in the future.

Keywords
Antibiotic resistance
Antimicrobial discovery
Public health
Misuse of antibiotics
Artificial intelligence
Drug development
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