Volume 10,Issue 4
Application of Denosumab Injection Combined with Basic Treatment in the Treatment of Elderly Female Patients with Osteoporosis
Objective: To explore the application effect of denosumab injection combined with basic treatment in the treatment of elderly female patients with osteoporosis. Methods: The elderly female patients with osteoporosis in our hospital from 2024.1 to 2025.7 were included. The total sample size included was 60 cases. They were divided into groups using the ball-touching method and different clinical treatments were carried out. The sample size included in the control group and the observation group were 30 cases. The corresponding treatment plan was basic treatment, denosumab injection combined with basic treatment. Results: The total effective rate of treatment in the observation group (96.67%) was higher than that in the control group (73.33%), P<0.05. The differences between the groups in electrolyte elements and bone metabolism indicators were small at the time of enrollment. After treatment, the levels of blood phosphorus, blood calcium, and bone alkaline phosphatase in the observation group were higher than those in the control group, and the level of type I collagen carboxyl terminal peptide β special sequence in the observation group was lower than that in the control group, P<0.05. The difference in bone density between the groups was small at the time of enrollment. After treatment, the bone density levels of lumbar spine L2-4 and total hip joint in the observation group were higher than those in the control group, P<0.05. There was no significant difference in the incidence of adverse reactions between the observation group and the control group (13.33%, 10.00%). The drug safety was equivalent between the groups, P>0.05. Conclusion: Elderly female patients with osteoporosis who receive denosumab injection combined with basic treatment have significant value in improving patient efficacy, improving electrolyte elements, bone metabolism, and bone density indicators, and are highly safe.
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