Volume 6,Issue 4
Plant-derived Extracellular Vesicles in the Central Nervous System: Emerging Mechanisms and Therapeutic Opportunities
Exosomes are nanoscale extracellular vesicles secreted by cells that transport proteins, nucleic acids and lipids, thereby mediating intercellular communication and regulating a wide range of physiological and pathological processes. In recent years, plant-derived extracellular vesicles have emerged as promising therapeutic agents, particularly for neurological disorders. This Review summarizes current knowledge of the biogenesis of plant exosomes, highlights their similarities and differences with animal-derived exosomes, and discusses the mechanisms governing their intercellular transfer. We further outline the molecular mechanisms underlying major neurological diseases and examine the signaling pathways through which plant-derived extracellular vesicles may exert neuroprotective and therapeutic effects. Together, these insights underscore the potential of plant-derived exosomes as a novel and versatile platform for the treatment of neurological disorders.
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