Volume 6,Issue 3
Coenzyme A and Its Derivatives in Metabolic Dormancy: A Multifaceted Regulatory Network
Metabolic dormancy is a survival strategy that can be found in bacteria, fungi, plants, and hibernating animals, to survive under unfavorable conditions, such as nutrient shortage and oxidative stress. Coenzyme A (CoA), a central metabolic molecule, plays an important role during dormancy by integrating energy metabolism, redox homeostasis, and post-translational modifications. This essay discusses the different roles of CoA and its derivatives in metabolic dormancy, particularly in enzyme activity control, stress adaptation, and gene expression. By integrating energy metabolism, gene regulation, and redox balance, CoA functions as a metabolic switch that helps cells enter, maintain, and exit dormancy and as an antioxidant to defend against oxidative stress. Understanding these mechanisms may provide evidence of bacterial persistence, hibernation, and metabolic diseases, with potential applications in biotechnology and medicine.
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