ARTICLE
25 February 2025

The maintenance mechanism of lysosomal membrane stability and its effect on the process of autophagy

Paula Navarro1*
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1 Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello, Santiago 8370146, Chile
CBR 2025 , 6(1), 34–38; https://doi.org/10.18063/amcmr.v1i3.007
© 2025 by the Author(s). Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

This article aims to delve into the maintenance mechanism of lysosomal membrane stability and its critical role in the process of autophagy. First, the basic structure and function of lysosomes are elaborated. Then, a detailed analysis of the mechanisms that maintain lysosomal membrane stability is provided, including the role of membrane proteins, the influence of lipid composition, and the regulation of intracellular environmental factors. Subsequently, the close connection between lysosomal membrane stability and the process of autophagy is explored, discussing aspects such as the fusion of autophagosomes with lysosomes, the release of lysosomal hydrolases, and activity regulation. Finally, future research directions for lysosomal membrane stability are prospected, aiming to provide a theoretical foundation and new ideas for research in related fields.

Keywords
Lysosome
Membrane stability
Autophagy
Maintenance mechanism
References

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Conflict of interest
The author declares no conflict of interest.
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