In the design of sound effects for mobile games, hardware limitations and diverse user needs remain the main challenges. Due to the processing power and memory limitations of mobile devices, sound designers need to find a balance between sound quality and resource utilization to ensure optimal performance of sound effects under limited resources. The compression, optimization, and compatibility issues of sound effect files also need to be addressed as a key focus. In addition, in response to users’ demand for personalized settings, sound design needs to provide rich sound options to meet the preferences of different players, while also considering the silent mode and low volume requirements, as well as the influence of cultural and language differences on sound design. This article provides a deep understanding of the field of mobile game sound design through the analysis of the application and challenges of new technologies and provides valuable references for future sound design practices and research.