Refined and chemical production has the characteristics of high temperature and pressure, flammable and explosive dangers, and intensive exposures to toxic and hazardous materials, typical high-risk characteristics. Plants are running around the clock, the process flows are complicated, the source of hazards is widespread, it is necessary to do a good job in safety management to ensure stable operation and protect the life and property of people. This report lays out a systematic analysis of where we are falling short today with respect to the refining and chemical safety MTTF, summarizes the design guidelines of the system, and refines key technologies in three directions: smart observation and forecasting, online equipment diagnostics, and emergency technology upgrades. Furthermore, it provides long-term protection by means of a standardized procedure, human resource training, and incentive assessment. It is based on practical experience within this industry: the research provides feasible recommendations on how to improve the SMS, which can offer a theoretical basis and reference for building up an advanced safety management system framework, minimizing significant risks, and encouraging effective, long-term safety management within the refining and chemical industry.