In the context of the “Healthy China 2030” strategy and the construction of “New Medicine” and “New Engineering”, higher requirements are put forward for the cultivation of composite talents with both technical ability and humanistic literacy. This article is based on an analysis of the “four major obstacles” in cultivating humanistic literacy–the lack of value rationality, the fragmentation of knowledge systems, the breakage of practical chains, and the fuzzy evaluation criteria. It proposes a three-dimensional collaborative operation mechanism of “knowledge ability value”: constructing a cognitive framework through interdisciplinary integration, strengthening ethical thinking and clinical empathy through ability cultivation. Further research proposes the introduction of ideological and political education to build a value bridge of “benevolence and skill”; Build a three-level curriculum system of “foundation core application” to connect the knowledge barriers of medical engineering; Building an interdisciplinary collaboration platform, relying on social practice and project-based learning to deepen scene immersion; Establish a “quantitative + qualitative” diversified evaluation mechanism, incorporate humanistic literacy into institutionalized assessments, and help cultivate high-quality composite talents who possess both moral and technical abilities.