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Volume 10,Issue 1

Fall 2025

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27 December 2024

The Role of B Lymphocyte Stimulator/A Proliferation-Inducing Ligand in Neuroimmune Diseases

Jie Ding1 Yangtai Guan1*
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1 Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
© 2024 by the Author(s). Licensee Whioce Publishing, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), both belonging to the tumor necrosis factor superfamily, exhibit significant homology. Functioning as lymphocyte co-stimulators, BLyS and APRIL regulate various biological processes, including cell differentiation, proliferation, survival, and importantly, immune functions of B and T cells. These molecules play a pivotal role in the pathogenesis and progression of neuroimmune diseases, such as neuromyelitis optica spectrum disorders, multiple sclerosis, and myasthenia gravis. This paper aims to enhance the understanding of BLyS/APRIL and their involvement in neuroimmune diseases.

Keywords
B-cell activating factor
A proliferation-inducing ligand
Neuroimmune diseases
Pathogenesis
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Conflict of interest
The authors declare no conflict of interest.
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