Volume 10,Issue 1
Fall 2025
The Role of Vitamin K in Vascular Calcification in Chronic Kidney Disease Patients
Vascular calcification is closely associated with the increased cardiovascular mortality rate in chronic kidney disease (CKD) patients and has a high prevalence. However, current treatment options and outcomes are limited. Matrix γ-carboxyglutamic acid protein is a physiological inhibitor of vascular calcification, and its production requires the involvement of vitamin K for physiological activity. Supplementing vitamin K may be an effective treatment for preventing and managing vascular calcification in CKD patients, particularly in maintenance hemodialysis (MHD) patients who may have widespread vitamin K deficiency. This article provides a review of the role of vitamin K in vascular calcification in CKD patients.
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