Objective: To analyze the core content and application value of perioperative comfort nursing model in patients undergoing uterine myomectomy. Methods: 70 patients were studied. All were diagnosed with uterine fibroids after admission to the hospital and underwent resection. After odd-even number grouping, 35 cases in each group were selected from February 2025 to February 2026. Among them, routine nursing was used in the control group, and comfort nursing mode was used in the experimental group to compare the effects. Results: (1) After counting the amount of intraoperative blood loss, the number of patients with uterine fibroids in the experimental group was lower than that of the control group, P < 0.05. The time to first postoperative exhaust gas and hospitalization time were shorter in the experimental group, P < 0.05. (2) Comparison of the VAS scores of patients with uterine myomectomy, the experimental group (2.19 ± 0.68 points) was lower, P < 0.05; in terms of the incidence of complications, the statistical data of the two groups were: 22.86% (8/35), 5.71% (2/35). The comparison results show that: (3) After perioperative routine care and comfort nursing intervention, the satisfaction rate of uterine fibroid patients in the control group was 77.14% (27/35), and that in the experimental group was 97.14% (34/35). In the comparison results, the experimental group was higher, P < 0.05. Conclusion: During the surgical treatment stage, the application of the comfort nursing model has significant advantages in many aspects. For patients with uterine fibroids, it can significantly reduce the amount of intraoperative bleeding, shorten the first postoperative exhaust time and hospitalization time, and reduce the incidence of complications. At the same time, this nursing program can also better reduce the patient’s pain and improve the level of satisfaction, and is worthy of widespread implementation.