Volume 11,Issue 4
Opioid-Free Anesthesia in Laparoscopic Bariatric Surgery: Outcomes and Recovery Quality Analysis
In order to explore the clinical value of opioid-free anesthesia (OFA) protocol in laparoscopic bariatric surgery, this research carried out a prospective randomized controlled trial. A total of 100 patients who needed elective laparoscopic bariatric surgery were recruited and then assigned randomly according to a 1:1 ratio to two groups (n = 50): the OFA group and opioid-based anesthesia (OBA) control group. Patients in the OFA group were administered multidrug anesthesia consisting of dexmedetomidine, lidocaine, esketamine, and NSAIDs, while those in the OBA group received routine anesthesia composed of sufentanil-propofol. Quality of Recovery-15 (QoR-15) score was regarded as the major endpoint. Other indicators such as intraoperative hemodynamic parameters, Numeric Rating Scale (NRS) pain scores, postoperative nausea and vomiting (PONV) incidence, and perioperative adverse events occurrence were also measured. Compared with the OBA group, OFA patients had much better QoR-15 scores (P < 0.001) at 24 and 48 hours postoperatively; their NRS pain scores were also smaller at every time point tested, while the percentage of patients suffering PONV fell from 38.0% to 10.0%; extubation time and PACU length of stay decreased accordingly and total hospitalization duration became shorter too; there was no increase in cases of hemodynamic instability.
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