Volume 11,Issue 4
Study on the Effects of Integrated Traditional Chinese and Western Medicine in Improving Gastroscopic and Pathological Findings in Patients with Chronic Atrophic Gastritis Accompanied by Intestinal Metaplasia
Objective: To assess the efficacy of the Integrated Traditional Chinese and Western Medicine (ICWM) program among patients with chronic atrophic gastritis (CAG) associated with intestinal metaplasia (IM) according to their endoscopic morphology and pathological alteration grade. Methods: It was implemented through a randomized controlled trial. There were 100 cases admitted to our hospital from June 2023 to December 2024 who were all suffering from CAG with IM, divided into the observation group (n = 50) and the control group (n = 50), according to the random sequence. Patients in the control group only received traditional Western medicines such as quadruple H. pylori eradication treatment plus mucosa protector. Patients in the observation group had another choice, namely decoctions based on invigorating the spleen and tonifying qi, activating blood circulation and removing blood stasis as well as detoxification according to TCM theories. The treatment period was six months. Efficacy was evaluated according to four aspects, including gastroscopic appearance score, OLGA/OLGIM stage classification of gastric lesion severity degree, serum indicators of PGⅠ, PGR, and G-17 levels, and scores of TCM syndromes. Results: Compared with the control group, all indicators in the observation group had obvious superiority (P < 0.05). Among them, the overall gastroscopic response rate reached 84.0% vs 62.0%; the percentage of OLGA staging regression cases was 72.0% vs 44.0%; the IM improvement rate was 66.0% vs 38.0%; while there were more patients with improvement of TCM syndromes in the observation group (88.0%) than in the control group (64.0%). Conclusion: Integrated Chinese and Western medicine has enhanced efficacy for treating patients with CAG associated with IM.
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