Volume 11,Issue 2
SOX10 in Neurodevelopment and Disease: Molecular Mechanisms, Pathological Models and Therapeutic Prospects
SOX10 is a neural crest transcription factor that preserves lineage competence and guides differentiation. Because it functions in enteric progenitors, Schwann cells, melanocytes, and auditory-supporting cells, reduced activity can produce multisystem disease. This review links SOX10-centered regulation to Waardenburg syndrome, Hirschsprung disease, deafness, and glial dysfunction, and highlights models that support mechanism-based therapy design.
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