Volume 10,Issue 3
Efficacy of External High-Frequency Hyperthermia Combined with Circulating Hyperthermic Perfusion Chemotherapy in the Treatment of Malignant Pleural and Peritoneal Effusions
Objective: To investigate the efficacy and safety of external high-frequency hyperthermia (HCPT) combined with circulating hyperthermic perfusion chemotherapy in the treatment of malignant pleural and peritoneal effusions. Methods: A retrospective analysis was conducted on 20 patients with malignant pleural effusions admitted to our hospital from January 2020 to December 2024 as the study group, and 20 patients before 2020 as the control group. Chemotherapy drugs such as doxorubicin hydrochloride injection, vinorelbine injection, and daunorubicin liposome were administered via circulating hyperthermic perfusion chemotherapy. The experimental group also received HCPT combined with hyperthermic perfusion chemotherapy once daily for three consecutive days, with the drug solution changed every three days. The improvement of clinical symptoms and the levels of blood tumor markers were observed. Results: The effective rate in the experimental group was 95%, significantly higher than 85% in the control group, but the difference was not statistically significant (P > 0.05). The levels of carcinoembryonic antigen (CEA), CA19-9, and CA72-4 significantly decreased compared to pre-treatment levels, with statistically significant differences (P < 0.05). Additionally, indicators such as serum lactate dehydrogenase (LDH), AST/ALT, and INR showed no correlation with changes in tumor marker levels (P > 0.05). Conclusion: HCPT combined with hyperthermic perfusion chemotherapy demonstrates favorable efficacy and safety in the treatment of malignant pleural and peritoneal effusions.
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